Supramolecular Catalysis of Ester and Amide Cleavage by a Dinuclear Barium(II) Complex

Roberta Cacciapaglia; Stefano Di Stefano; Erik Kelderman; Luigi Mandolini

doi:10.1002/(SICI)1521-3773(19990201)38:3<348::AID-ANIE348>3.0.CO;2-D

Supramolecular Catalysis of Ester and Amide Cleavage by a Dinuclear Barium(II) Complex

Angew Chem Int Ed Engl. 1999 Feb 1;38(3):348-351. doi: 10.1002/(SICI)1521-3773(19990201)38:3<348::AID-ANIE348>3.0.CO;2-D.

Authors

Roberta Cacciapaglia¹, Stefano Di Stefano¹, Erik Kelderman¹, Luigi Mandolini¹

Affiliation

¹ Dipartimento di Chimica and Centro CNR di Studio sui Meccanismi di Reazione, Università La Sapienza, Box 34-ROMA 62, I-00185 Roma (Italy), Fax: (+390) 6-490421.

PMID: 29711642
DOI: 10.1002/(SICI)1521-3773(19990201)38:3<348::AID-ANIE348>3.0.CO;2-D

Abstract

Five components spontaneously self-assemble to yield the productive complex 1, where one barium ion delivers an ethoxide to the carbonyl group of an amide substrate anchored by means of a distal carboxylate moiety to the other barium ion. High substrate specificity, fairly high reaction rates with catalytic turnover, and competitive inhibition by inert substrates are observed.

Keywords: Alkaline earth metals; Enzyme mimetics; Macrocyclic ligands; Supramolecular chemistry.