Clinically relevant relaxivity enhancement of a magnetic resonance imaging (MRI) contrast agent has been achieved by using prodrug Gd3+ complexes (see picture, DTPA=diethylenetriaminepentaaceto). Enzymatic cleavage of lysine residues from the prodrug exposes a group that has a high affinity to human serum albumin and promotes enhanced relaxivity, thus enabling the detection of targets at submicromolar concentrations.
Keywords: MRI; chelates; inhibitors; lanthanides; peptides.
© 2001 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany.