doi: 10.1002/1521-3773(20010903)40:17<3228::AID-ANIE3228>3.0.CO;2-Q.
The Use of Carbon Monoxide and Imines as Peptide Derivative Synthons: A Facile Palladium-Catalyzed Synthesis of α-Amino Acid Derived Imidazolines
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- PMID: 29712039
- DOI: 10.1002/1521-3773(20010903)40:17<3228::AID-ANIE3228>3.0.CO;2-Q
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The Use of Carbon Monoxide and Imines as Peptide Derivative Synthons: A Facile Palladium-Catalyzed Synthesis of α-Amino Acid Derived Imidazolines
Angew Chem Int Ed Engl.
.
Abstract
One of the most facile routes to prepare carboxylate-substituted imidazolines is by the palladium-catalyzed coupling of an imine, carbon monoxide, and an acid chloride. In this reaction, a peptide unit is constructed and directly incorporated into the heterocyclic core.
Keywords: homogeneous catalysis; multicomponent reactions; nitrogen heterocycles; palladium; peptides.
© 2001 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany.
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