PASSflow Syntheses Using Functionalized Monolithic Polymer/Glass Composites in Flow-Through Microreactors

Angew Chem Int Ed Engl. 2001 Nov 5;40(21):3995-3998. doi: 10.1002/1521-3773(20011105)40:21<3995::AID-ANIE3995>3.0.CO;2-V.

Abstract

A chemistapos;s wish finally becomes reality: microreactors for every synthetic laboratory! By precipitation polymerization various polymers are introduced into the irregular pore system of a porous glass rod. By embedding these rods into a housing, followed by functionalization and immobilization of reagents onto the polymer phase, versatile microreactors are obtained. With this apparatus, chemical transformations in solution can be performed, for example, a steroid derivatization.

Keywords: immobilization; microreactor; polymerization; solid-phase syntheses; synthetic methods.