The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function

Science. 1988 Sep 23;241(4873):1632-9. doi: 10.1126/science.2971269.


The study of human hematopoietic cells and the human immune system is hampered by the lack of a suitable experimental model. Experimental data are presented showing that human fetal liver hematopoietic cells, human fetal thymus, and human fetal lymph node support the differentiation of mature human T cells and B cells after engraftment into mice with genetically determined severe combined immunodeficiency. The resultant SCID-hu mice are found to have a transient wave of human CD4+ and CD8+ T cells and human IgG (immunoglobulin G) in the peripheral circulation. The functional status of the human immune system within this mouse model is not yet known.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • B-Lymphocytes / physiology
  • Cell Differentiation
  • Chimera*
  • Hematopoietic Stem Cells / physiology*
  • Humans
  • Liver / cytology
  • Liver Transplantation
  • Lymph Nodes / transplantation
  • Mice
  • Mice, Mutant Strains / immunology*
  • Models, Biological*
  • T-Lymphocytes / physiology
  • T-Lymphocytes, Helper-Inducer / immunology
  • T-Lymphocytes, Regulatory / immunology
  • Thymus Gland / anatomy & histology
  • Thymus Gland / physiology
  • Thymus Gland / transplantation
  • Transplantation, Heterologous