Transplant Drug Interactions and a Word of Caution for the HIV Provider. A Case Report

Open Forum Infect Dis. 2018 Apr 5;5(4):ofy070. doi: 10.1093/ofid/ofy070. eCollection 2018 Apr.


Electronic medical record platforms fail to support provider alerts when a drug is discontinued. Protease inhibitors, often boosted by ritonavir or cobicistat, increase the serum concentration of calcineurin inhibitors. This case demonstrates acute liver transplant rejection in an HIV-positive recipient due to a failure to recognize the loss of protease inhibitor interaction with his immunosuppressive regimen.

Keywords: HIV; drug interactions; electronic medical records; transplantation.

Publication types

  • Case Reports