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Review
. 2018 Apr 30;20(4):36.
doi: 10.1007/s11906-018-0833-7.

The Role of Interleukin-10 in the Pathophysiology of Preeclampsia

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Review

The Role of Interleukin-10 in the Pathophysiology of Preeclampsia

Hajrunisa Cubro et al. Curr Hypertens Rep. .

Abstract

Purpose of review: The pathophysiology of preeclampsia is complex and not entirely understood. A key feature in preeclampsia development is an immunological imbalance that shifts the maternal immune response from one of tolerance towards one promoting chronic inflammation and endothelial dysfunction. As a key regulator of immunity, IL-10 not only has immunomodulatory activity, but also directly benefits vasculature and promotes successful cellular interactions at the maternal-fetal interface. Here we focus on the mechanisms by which the dysregulation of IL-10 may contribute to the pathophysiology of preeclampsia.

Recent findings: Dysregulation of IL-10 has been demonstrated in various animal models of preeclampsia. Decreased IL-10 production in both placenta and peripheral blood mononuclear cells has been reported in human studies, but with inconsistent results. The significance of IL-10 in preeclampsia has shifted from a key biomarker to one with therapeutic potential. As such, a better understanding of the role of this cytokine in the pathophysiology of preeclampsia is of paramount importance.

Keywords: Cytokines; Hypertension; Inflammation; Interleukin 10; Preeclampsia; Regulatory T cells; Vascular activity.

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