Abstract
We used the concept of chemical space to explore a virtual library of bicyclic peptides formed by double thioether cyclization of a precursor linear peptide, and identified an antimicrobial bicyclic peptide (AMBP) with remarkable activity against several MDR strains of Acinetobacter baumannii and Pseudomonas aeruginosa.
MeSH terms
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Acinetobacter baumannii / drug effects
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Antimicrobial Cationic Peptides / chemistry
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Antimicrobial Cationic Peptides / pharmacology*
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Bacillus subtilis / drug effects
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Biofilms / drug effects
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Cell Membrane / drug effects
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Drug Evaluation, Preclinical / methods
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Drug Resistance, Multiple, Bacterial / drug effects*
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Humans
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Microbial Sensitivity Tests
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Molecular Dynamics Simulation
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Peptides, Cyclic / chemistry
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Peptides, Cyclic / pharmacology*
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Protein Structure, Secondary
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Pseudomonas aeruginosa / drug effects
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Small Molecule Libraries / chemistry
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Small Molecule Libraries / pharmacology
Substances
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Anti-Bacterial Agents
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Antimicrobial Cationic Peptides
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Peptides, Cyclic
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Small Molecule Libraries