Lateralized Periodic Discharges: A Literature Review

J Clin Neurophysiol. 2018 May;35(3):189-198. doi: 10.1097/WNP.0000000000000448.


The purpose of this article is to provide a comprehensive review of the literature about a particular EEG pattern, lateralized periodic discharges (LPDs), or periodic lateralized epileptiform discharges (PLEDs). The review will discuss the history and terminology of LPDs and provide a detailed summary of the etiologies, pathophysiology, clinical symptoms, and imaging studies related to LPDs. Current controversies about the association of LPDs with seizures and their management will be reviewed. Finally, some unanswered questions and suggestions for future research on LPDs will be discussed.

Publication types

  • Review

MeSH terms

  • Brain / diagnostic imaging
  • Brain / physiopathology*
  • Electroencephalography* / classification
  • Epilepsy / classification
  • Epilepsy / diagnosis*
  • Epilepsy / physiopathology*
  • Epilepsy / therapy
  • Functional Laterality*
  • Humans
  • Periodicity
  • Terminology as Topic