Lymphoepithelioma-like carcinoma of the skin

An Bras Dermatol. 2018 Mar;93(2):256-258. doi: 10.1590/abd1806-4841.20187205.

Abstract

Primary cutaneous lymphoepithelioma-like carcinoma is a rare disease with low metastatic potential. Its morphologic and pathological features are similar to those of nasopharyngeal lymphoepithelial carcinoma. We report the case of a 60-year-old man with an infrapalpebral pearly papule, measuring 0.6 cm in diameter. The lesion was excised with a clinical hypothesis of basal cell carcinoma or squamous cell carcinoma. Histopathological analysis revealed a malignant neoplasm with syncytial arrangement of cells with vesicular nuclei, associated with dense lymphocytic infiltrate. Immunohistochemistry revealed cytokeratin-positive cells (AE1/AE3) and p63 protein, indicating epithelial histogenesis and squamous differentiation. A negative Epstein-Barr virus test result was achieved by immunohistochemistry. Primary lymphoepithelioma-like carcinoma of the skin is a differential diagnosis of lesions with prominent inflammatory infiltrates.

Publication types

  • Case Reports

MeSH terms

  • Biopsy
  • Carcinoma / pathology*
  • Carcinoma, Basal Cell / pathology
  • Carcinoma, Squamous Cell / pathology
  • Diagnosis, Differential
  • Epithelial Cells / pathology
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Skin Neoplasms / pathology*