Dopamine Is Differentially Encoded by D2 Receptors in Striatal Subregions

Neuron. 2018 May 2;98(3):459-461. doi: 10.1016/j.neuron.2018.04.016.

Abstract

Striatal dopamine signaling is differentially regulated along the dorso-ventral axis, but how these differences are encoded by dopamine receptors is unknown. In this issue of Neuron, Marcott et al. (2018) show that dopamine activates D2 receptors in regionally distinct ways and dissect the underlying mechanisms behind striatal D2 heterogeneity.

Keywords: D2 receptors; Parkinson’s disease; addiction; dopamine; dorsal striatum; nucleus accumbens; schizophrenia.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Corpus Striatum
  • Dopamine*
  • Neurons
  • Nucleus Accumbens*
  • Receptors, Dopamine D2

Substances

  • Receptors, Dopamine D2
  • Dopamine