The integrated molecular interactions of proteins can create active biological networks whose material properties and actions can impact a variety of physiological processes. Chief among these is the ability to generate and respond to physical forces. The cytoskeleton plays a key role in this behavior, characterized by active self-reorganization to control a cell's shape and mediate its physical interactions. This review discusses our current understanding of how the material properties of the cytoskeleton and its physical interactions with the extracellular environment impact cell migration.
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