Coronary Artery Disease in Patients ≥80 Years of Age

J Am Coll Cardiol. 2018 May 8;71(18):2015-2040. doi: 10.1016/j.jacc.2017.12.068.


Coronary artery disease (CAD) is a major cause of morbidity and mortality in patients ≥80 years of age. Nonetheless, older patients have typically been under-represented in cardiovascular clinical trials. Understanding the pathophysiology, epidemiology, and optimal means of diagnosis and treatment of CAD in older adults is crucial to improving outcomes in this high-risk population. A patient-centered approach, taking into account health status, functional ability and frailty, cognitive skills, and patient preferences is essential when caring for older adults with CAD. The present systematic review focuses on the current knowledge base, gaps in understanding, and directions for future investigation pertaining to CAD in patients ≥80 years of age.

Keywords: coronary artery disease; geriatric cardiology; octogenarians.

Publication types

  • Systematic Review

MeSH terms

  • Aged, 80 and over
  • Coronary Artery Disease / diagnosis
  • Coronary Artery Disease / etiology
  • Coronary Artery Disease / mortality
  • Coronary Artery Disease / therapy*
  • Humans