Urothelial carcinoma in children: A case series

Bull Cancer. 2018 Jun;105(6):556-561. doi: 10.1016/j.bulcan.2018.03.002. Epub 2018 May 1.


Objective: To report a series of 5 patients with urothelial bladder cancer (UBC) three of them with a history of exposure to amines and only two with gross hematuria.

Materials and methods: After obtaining ethical and legal authorization, we performed a restrospective monocentric study. We collected information of patients with UBC over a period of 10 years. We recorded: age, sex, reason for presentation, familial history and risk factors, preoperative assessment, surgical details, histological type and grade, follow-up.

Results: 2 children came to our attention for hematuria and 3 for incidental bladder mass finding, at a median age of 11.8 years. We performed microscopically complete transurethral resection of the tumor (TURB). Median tumor size was 1.8cm. No further therapy was required. All cancers belonged to NMIBC (Non-muscle-invasive Bladder Cancer) considering the 2004 WHO classification: 2 urothelial papillomas, 2 papillary tumors with low grade malignancy (PUN-LPM) and 1 papillary urothelial carcinoma of low histological grade (LG-PUC Ta, N0, M0). There was not any complications and no relapse occurred during follow-up (median 30 months).

Conclusions: In this study, UBCs presenting at a young age were low-grade and have not recurred in follow-up. This confirms the results of other series reported in Literature. Therefore there might be the space to perform a follow-up dedicated to children.

Keywords: Cystoscopy; Hematuria; Pediatric urology; Transurethral resection of the bladder; Urothelial bladder cancer.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Amines / adverse effects
  • Carcinoma, Papillary* / complications
  • Carcinoma, Papillary* / pathology
  • Carcinoma, Papillary* / surgery
  • Child
  • Female
  • Hematuria / etiology
  • Humans
  • Incidental Findings
  • Male
  • Papilloma* / complications
  • Papilloma* / pathology
  • Papilloma* / surgery
  • Retrospective Studies
  • Risk Factors
  • Tumor Burden
  • Urinary Bladder Neoplasms* / complications
  • Urinary Bladder Neoplasms* / pathology
  • Urinary Bladder Neoplasms* / surgery


  • Amines