Surgical Treatment for Extramammary Paget's Disease

Curr Treat Options Oncol. 2018 May 3;19(6):27. doi: 10.1007/s11864-018-0545-x.


Extramammary Paget's disease (EMPD) is a rare, slow growing non-melanoma skin cancer.Diagnosis is often significantly delayed, since clinical presentation may resemble common benign dermatoses. Treatment is characterized by high recurrence rates. This is in part due to ill-defined margins and by frequent development of satellites. Improvement of outcome needs a better preoperative planning with fluorescence diagnostics or scouting biopsies. Mohs micrographic surgery has some advantages for patients, such as reduced relapse rates and prolonged relapse-free survival. Improved identification of Paget cells in cryosections by immunostainings or alternatively the use of delayed Mohs with formalin-fixed material reduces the rate of false-negative results. Surgery remains the cornerstone of treatment.

Keywords: Extramammary Paget’s disease; Laser surgery; Non-melanoma skin cancer; Surgery.

Publication types

  • Review

MeSH terms

  • Biopsy
  • Combined Modality Therapy
  • Diagnosis, Differential
  • Diagnostic Imaging
  • Disease Management
  • Humans
  • Neoplasm Metastasis
  • Neoplasm Staging
  • Paget Disease, Extramammary / diagnosis
  • Paget Disease, Extramammary / etiology
  • Paget Disease, Extramammary / surgery*
  • Plastic Surgery Procedures
  • Sentinel Lymph Node Biopsy
  • Treatment Outcome