The medicinal mushroom Auricularia auricula- judae (Bull.) extract has antioxidant activity and promotes procollagen biosynthesis in HaCaT cells

Nat Prod Res. 2019 Nov;33(22):3283-3286. doi: 10.1080/14786419.2018.1468332. Epub 2018 May 4.


In this study, Auricularia auricula-judae (Bull.) extract (AAE) had potent antioxidant activity in vitro and promoted the biosynthesis of procollagen, a precursor of collagen in HaCaT cells. In addition, the expression of HAS-3 (hyaluronic acid synthase), which is a moisturizing factor, was increased in HaCaT cells in response to AAE. Therefore, this work suggests that AAE has the potential to exhibit antioxidant activity and promote procollagen biosynthesis in HaCaT cells.

Keywords: -; - (Bull.); HaCaT cells; antioxidant; collagen; mushroom; skin.

MeSH terms

  • Agaricales / chemistry*
  • Antioxidants / chemistry
  • Antioxidants / isolation & purification*
  • Antioxidants / pharmacology
  • Basidiomycota
  • Cell Line
  • Humans
  • Hyaluronan Synthases / drug effects
  • Hyaluronan Synthases / metabolism
  • Procollagen / biosynthesis*
  • Procollagen / drug effects
  • Skin / cytology
  • Skin / enzymology
  • Skin / metabolism


  • Antioxidants
  • Procollagen
  • HAS3 protein, human
  • Hyaluronan Synthases