Relationship of the oxidative damage biomarker 8-epi-prostaglandin F2α to risk of lung cancer development in the Shanghai Cohort Study

Carcinogenesis. 2018 Jul 3;39(7):948-954. doi: 10.1093/carcin/bgy060.

Abstract

It has been hypothesized that the pathogenesis of lung cancer induced by cigarette smoking involves oxidative damage by free radicals. Epidemiological data on biomarkers of oxidative damage and risk of lung cancer development are sparse. A nested case-control study of 610 lung cancer cases and 610 matched controls was conducted within a prospective cohort of 18 244 Chinese men in Shanghai, China. The concentrations of 8-epi-prostaglandin F2α (8-epiPGF2α), a biomarker of oxidative stress, were determined in baseline urine samples using a validated mass-spectrometry assay. Current smokers had significantly higher level of 8-epiPGF2α than former smokers or never smokers (P < 0.001). 8-epiPGF2α levels were significantly higher in lung cancer cases than their smoking-matched controls in former and current smokers, but not different in never smokers (P for interaction = 0.019). The relative risks of developing lung cancer for former and current smokers in the highest relative to the lowest quartile of 8-epiPGF2α were 5.25 (Ptrend = 0.035) and 1.99 (Ptrend =0.007), respectively. The effect of 8-epiPGF2α and biomarkers of cigarette smoke exposure on lung cancer risk was additive; the relative risk was 5.33 (95% confidence interval = 2.65-7.51) for current smokers with the highest thirds of 8-epiPGF2α and total cotinine compared with their lowest thirds. Smokers with a heightened state of oxidative stress in response to the insults of cigarette smoking may be more susceptible to smoking-induced lung carcinogenesis.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Biomarkers / urine*
  • Case-Control Studies
  • China
  • Dinoprost / analogs & derivatives*
  • Dinoprost / urine
  • Female
  • Humans
  • Lung Neoplasms / etiology*
  • Lung Neoplasms / urine*
  • Male
  • Middle Aged
  • Nicotiana / adverse effects
  • Oxidative Stress / drug effects*
  • Prospective Studies
  • Risk Factors
  • Smoke / adverse effects
  • Smoking / adverse effects
  • Smoking / urine

Substances

  • Biomarkers
  • Smoke
  • 8-epi-prostaglandin F2alpha
  • Dinoprost