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, 22 (5), 616-618

Crinkle-Cut Brain Organoids

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Crinkle-Cut Brain Organoids

Madeline A Lancaster. Cell Stem Cell.

Abstract

In large mammalian brains, including those of humans, the surface of the cortex is highly folded. How these convolutions form is still unclear, but recent work in Nature Physics by Karzbrun et al. (2018) supports a mechanism involving differential surface swelling combined with internal constraint.

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