Validation of a Simple Disease-Specific, Quality-Of-Life Measure for Diabetic Polyneuropathy: CAPPRI

Neurology. 2018 Jun 5;90(23):e2034-e2041. doi: 10.1212/WNL.0000000000005643. Epub 2018 May 4.


Objective: We studied the performance of a 15-item, health-related quality-of-life polyneuropathy scale in the clinic setting in patients with diabetic distal sensorimotor polyneuropathy (DSPN).

Methods: Patients with DSPN from 11 academic sites completed a total of 231 Chronic Acquired Polyneuropathy Patient-Reported Index (CAPPRI) scales during their clinic visits. Conventional and modern psychometric analyses were performed on the completed forms.

Results: Conventional and modern analyses generally indicated excellent psychometric properties of the CAPPRI in patients with DSPN. For example, the CAPPRI demonstrated unidimensionality and performed like an interval-level scale.

Conclusion: Attributes of the CAPPRI for DSPN include ease of use and interpretation; unidimensionality, allowing scores to be summed; adequate coverage of disease severity; and the scale's ability to address relevant life domains. Furthermore, the CAPPRI is free and in the public domain. The CAPPRI may assist the clinician and patient with DSPN in estimating disease-specific quality of life, especially in terms of pain, sleep, psychological well-being, and everyday function. The CAPPRI may be most useful in the everyday clinical setting but merits further study in this setting, as well as the clinical trial setting.

Publication types

  • Multicenter Study

MeSH terms

  • Adult
  • Canada / epidemiology
  • Diabetic Neuropathies / epidemiology
  • Diabetic Neuropathies / psychology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Psychometrics*
  • Quality of Life / psychology*
  • Reproducibility of Results
  • Retrospective Studies
  • Severity of Illness Index*
  • United States / epidemiology