Improved anticancer properties of stem cells derived exosomes by prolonged release from PCL nanofibrous structure

Gene. 2018 Jul 30:665:105-110. doi: 10.1016/j.gene.2018.05.003. Epub 2018 May 2.

Abstract

Systemic chemotherapy as a routine method for the treatment of cancers has several complications. Localized chemotherapy can significantly increase the treatment efficacy and reduce side effects. Here, mesenchymal stem cells derived microvesicles (MVs) was incorporated into Polycaprolactone nanofibers and then the apoptotic behavior of MCF-7 breast cancer cells was investigated while cultured on MVs-Polycaprolactone by using SEM, MTT and apoptotic gene expression. Results demonstrated that MVs-Polycaprolactone group was shown a great apoptosis induction potential into MCF-7 cells and it can be concluded that MVs-Polycaprolactone has a great promising potential to introduce as an in-situ tumor inhibitor construct rather than chemo-drugs.

Keywords: Breast cancer; Mesenchymal stem cells; Microvesicles; Polycaprolactone.

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Apoptosis / drug effects*
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / metabolism*
  • Breast Neoplasms / pathology
  • Exosomes / metabolism*
  • Exosomes / pathology
  • Female
  • Humans
  • MCF-7 Cells
  • Mesenchymal Stem Cells / metabolism*
  • Mesenchymal Stem Cells / pathology
  • Nanofibers / chemistry*
  • Polyesters* / chemistry
  • Polyesters* / pharmacology

Substances

  • Antineoplastic Agents
  • Polyesters
  • polycaprolactone