Intradiscal ozone therapy for lumbar disc herniation

Cell Mol Biol (Noisy-le-grand). 2018 Apr 30;64(5):52-55.

Abstract

The rationale behind intradiscal O2-O3 therapy is the pain elicited by the mechanical compression of the nerve root, which is associated with periganglionic and periradicular inflammation. This study aimed to determine the effect of intradiscal ozone injection on pain score and satisfaction of patients with low back pain (LBP) secondary to disc herniation. Patients with LBP diagnosed with disc herniation were enrolled in this clinical trial. After prepping and draping the area, intradiscal injection of ozone/oxygen mixture (10 ml, 25μg/ml) was performed under fluoroscopy guide (c-arm). Pain score and patient satisfaction were assessed prior to the injection (baseline) and 1, 3, 6, 12 and 24 months after the injection. Sixty three patients (24 males, 39 females) with mean age of 53.3 ±2.0 y enrolled in the study. The mean±standard deviation (SD) of pain score before intervention was 6.968 ±0.11. Pain score was reduced to 4.25±0.19 at 1 month, 4.33±0.20 at 3 months, 4.87 ±0.21 at 6 months and 5.22 ±0.20 at 24 months. According to the modified MacNab scale success of pain relief was as follows: excellent: 4 (6.3%), good: 17 (26.98 %), sufficient: 13 (20.63 %), poor: 13 (20.63 %), no result: 11 (17.46%), negative: 4 (6.3 %). Intradiscal ozone therapy was determined to provide improved outcomes in patients with single level of bulging and protrusion.

Keywords: Intradiscal ozone; Lumbar disc herniation; Pain score; Patient satisfaction..

Publication types

  • Clinical Trial

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Female
  • Fluoroscopy
  • Humans
  • Injections, Intralesional
  • Intervertebral Disc / diagnostic imaging
  • Intervertebral Disc / drug effects
  • Intervertebral Disc / innervation
  • Intervertebral Disc / pathology
  • Intervertebral Disc Displacement / diagnostic imaging
  • Intervertebral Disc Displacement / drug therapy*
  • Intervertebral Disc Displacement / pathology
  • Low Back Pain / diagnostic imaging
  • Low Back Pain / drug therapy*
  • Low Back Pain / pathology
  • Lumbar Vertebrae / diagnostic imaging
  • Lumbar Vertebrae / drug effects
  • Lumbar Vertebrae / innervation
  • Lumbar Vertebrae / pathology
  • Male
  • Middle Aged
  • Oxygen / therapeutic use*
  • Ozone / therapeutic use*
  • Pain Measurement / statistics & numerical data
  • Patient Satisfaction / statistics & numerical data
  • Treatment Outcome

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Ozone
  • Oxygen