Poria cocos Wolf extracts represses pigmentation in vitro and in vivo

Cell Mol Biol (Noisy-le-grand). 2018 Apr 30;64(5):80-84.

Abstract

In skin, melanocytes determine skin color using melanogenesis, which induces protective mechanism to oxidative stress and UV damage. However, when melanin is excessive produced by the various stimulus, the accumulated melanin induces hyperpigmentation disease such as melasma, freckles, Melanism ware induced. Therefore, it is implicated to finding potential agents for whitening to be used in cosmetic products. In our present study, we show that Poria cocos Wolf extracts decreased melanin synthesis in B16F10. And then this inhibition of melanogenesis was provoked by regulation of tyrosinase activity and tyrosinase and MITF expression. Moreover, Poria cocos Wolf extracts contained cream improved skin tone using increase of bright value. Overall, these results provide evidence to potential agent for whitening to be used in cosmetic products.

Keywords: B16F10; MITF; Melanogenesis; Poria cocos Wolf; Tyrosinase; Whitening..

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Agaricales / chemistry
  • Animals
  • Cell Line, Tumor
  • Double-Blind Method
  • Female
  • Fungal Proteins / antagonists & inhibitors
  • Fungal Proteins / isolation & purification
  • Fungal Proteins / metabolism
  • Gene Expression Regulation
  • Humans
  • Melanins / antagonists & inhibitors*
  • Melanins / biosynthesis
  • Melanocytes / drug effects*
  • Melanocytes / enzymology
  • Melanocytes / pathology
  • Melanoma, Experimental / enzymology
  • Melanoma, Experimental / genetics
  • Melanoma, Experimental / pathology
  • Mice
  • Microphthalmia-Associated Transcription Factor / antagonists & inhibitors
  • Microphthalmia-Associated Transcription Factor / genetics
  • Microphthalmia-Associated Transcription Factor / metabolism
  • Monophenol Monooxygenase / antagonists & inhibitors*
  • Monophenol Monooxygenase / genetics
  • Monophenol Monooxygenase / metabolism
  • Pigmentation / drug effects
  • Pigmentation / genetics
  • Plant Extracts / chemistry
  • Skin / drug effects*
  • Skin / enzymology
  • Skin Lightening Preparations / isolation & purification
  • Skin Lightening Preparations / pharmacology*
  • Skin Neoplasms / enzymology
  • Skin Neoplasms / genetics
  • Skin Neoplasms / pathology
  • Wolfiporia / chemistry*

Substances

  • Fungal Proteins
  • Melanins
  • Microphthalmia-Associated Transcription Factor
  • Mitf protein, mouse
  • Plant Extracts
  • Skin Lightening Preparations
  • Monophenol Monooxygenase