Natural scaffolds in anticancer therapy and precision medicine

Aloran Mazumder; Claudia Cerella; Marc Diederich

doi:10.1016/j.biotechadv.2018.04.009

Natural scaffolds in anticancer therapy and precision medicine

Biotechnol Adv. 2018 Nov 1;36(6):1563-1585. doi: 10.1016/j.biotechadv.2018.04.009. Epub 2018 May 3.

Authors

Aloran Mazumder¹, Claudia Cerella², Marc Diederich³

Affiliations

¹ Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 151-742, South Korea.
² Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Hôpital Kirchberg, 9, rue Edward Steichen, L-2540 Luxembourg, Luxembourg.
³ Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 151-742, South Korea. Electronic address: marcdiederich@snu.ac.kr.

PMID: 29729870
DOI: 10.1016/j.biotechadv.2018.04.009

Abstract

The diversity of natural compounds is essential for their mechanism of action. The source, structures and structure activity relationship of natural compounds contributed to the development of new classes of chemotherapy agents for over 40 years. The availability of combinatorial chemistry and high-throughput screening has fueled the challenge to identify novel compounds that mimic nature's chemistry and to predict their macromolecular targets. Combining conventional and targeted therapies helped to successfully overcome drug resistance and prolong disease-free survival. Here, we aim to provide an overview of preclinical investigated natural compounds alone and in combination to further improve personalization of cancer treatment.

Keywords: Chemotherapy; Natural compounds; Precision medicine; Targeted therapy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Antineoplastic Agents*
Biological Products*
Drug Design*
Humans
Precision Medicine*

Substances

Antineoplastic Agents
Biological Products