Trade-off of cerebello-cortical and cortico-cortical functional networks for planning in 6-year-old children

Neuroimage. 2018 Aug 1;176:510-517. doi: 10.1016/j.neuroimage.2018.04.067. Epub 2018 May 3.

Abstract

Childhood is a critical period for the development of cognitive planning. There is a lack of knowledge on its neural mechanisms in children. This study aimed to examine cerebello-cortical and cortico-cortical functional connectivity in association with planning skills in 6-year-olds (n = 76). We identified the cerebello-cortical and cortico-cortical functional networks related to cognitive planning using activation likelihood estimation (ALE) meta-analysis on existing functional imaging studies on spatial planning, and data-driven independent component analysis (ICA) of children's resting-state functional MRI (rs-fMRI). We investigated associations of cerebello-cortical and cortico-cortical functional connectivity with planning ability in 6-year-olds, as assessed using the Stockings of Cambridge task. Long-range functional connectivity of two cerebellar networks (lobules VI and lateral VIIa) with the prefrontal and premotor cortex were greater in children with poorer planning ability. In contrast, cortico-cortical association networks were not associated with the performance of planning in children. These results highlighted the key contribution of the lateral cerebello-frontal functional connectivity, but not cortico-cortical association functional connectivity, for planning ability in 6-year-olds. Our results suggested that brain adaptation to the acquisition of planning ability during childhood is partially achieved through the engagement of the cerebello-cortical functional connectivity.

Keywords: Activation likelihood estimation; Cerebellum; Cerebrum; Resting-state fMRI; Stockings of Cambridge; Tower of London.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cerebellum / diagnostic imaging
  • Cerebellum / physiology*
  • Cerebral Cortex / diagnostic imaging
  • Cerebral Cortex / physiology*
  • Child
  • Child Development / physiology*
  • Connectome / methods*
  • Executive Function / physiology*
  • Humans
  • Magnetic Resonance Imaging
  • Nerve Net / physiology*
  • Psychomotor Performance / physiology*