Urinary Liver Type Fatty Acid Binding Protein Is Negatively Associated With Estimated Glomerular Filtration Rate in Renal Transplant Recipients With Graft Loss

Transplant Proc. 2018 May;50(4):1083-1086. doi: 10.1016/j.transproceed.2018.01.029.

Abstract

Background: Liver type fatty acid binding protein (L-FABP) is abundant not only in the liver but also in the kidney and is excreted in urine. Its primary function is to facilitate intracellular long chain fatty acid transport and it might also act as an endogenous antioxidant molecular. The purpose of this study was to investigate whether plasma or urinary L-FABP levels were associated with graft function in renal transplant recipients.

Patients and methods: Sixty-seven renal transplant recipients with a mean age of 48.8 years were recruited. The mean duration of renal transplantation was 4131 days. Recipients were divided into 2 groups based on their estimated glomerular filtration rate (eGFR) values: moderate graft function (eGFR ≥60 mL/min/1.73 m2) and low graft function (eGFR <60 mL/min/1.73 m2). Fasting plasma and urinary L-FABP levels were measured.

Results: There was no significant difference in plasma L-FABP level between the 2 groups, although recipients in the low graft function group had significantly lower urinary L-FABP level when compared with recipients in the moderate graft function group. Plasma and urinary L-FABP levels were not associated with eGFR in the 67 recipients; however, urinary L-FABP level (β = -1.24, P = .037) and level adjusted by urinary creatinine (β = -0.75, P = .046) were significantly negatively associated with eGFR in recipients with low graft function after adjusting for potential confounders.

Conclusion: Increased urinary L-FABP level seems to be a significant indicator of decreased graft function in renal transplant recipients with loss of graft function.

MeSH terms

  • Adult
  • Biomarkers / urine*
  • Cross-Sectional Studies
  • Fatty Acid-Binding Proteins / urine*
  • Female
  • Glomerular Filtration Rate
  • Graft Survival*
  • Humans
  • Kidney Function Tests
  • Kidney Transplantation* / adverse effects
  • Male
  • Middle Aged
  • Transplant Recipients

Substances

  • Biomarkers
  • FABP1 protein, human
  • Fatty Acid-Binding Proteins