Precision Medicine: From Science To Value

Health Aff (Millwood). 2018 May;37(5):694-701. doi: 10.1377/hlthaff.2017.1624.


Precision medicine is making an impact on patients, health care delivery systems, and research participants in ways that were only imagined fifteen years ago when the human genome was first sequenced. Discovery of disease-causing and drug-response genetic variants has accelerated, while adoption into clinical medicine has lagged. We define precision medicine and the stakeholder community required to enable its integration into research and health care. We explore the intersection of data science, analytics, and precision medicine in the formation of health systems that carry out research in the context of clinical care and that optimize the tools and information used to deliver improved patient outcomes. We provide examples of real-world impact and conclude with a policy and economic agenda necessary for the adoption of this new paradigm of health care both in the United States and globally.

Keywords: Digital Health; Genomic Medicine; Genomics; Medicine/Clinical Issues; Precision Medicine.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Delivery of Health Care / organization & administration*
  • Female
  • Forecasting
  • Genetic Testing*
  • Genome, Human
  • Genomics*
  • Health Policy / legislation & jurisprudence
  • Humans
  • Information Dissemination
  • Male
  • Policy Making
  • Precision Medicine / methods*
  • Precision Medicine / trends
  • Public Health / trends
  • Quality of Health Care*
  • Risk Assessment
  • Translational Research, Biomedical
  • United States