Pediatric Intestinal Transplantation

Gastroenterol Clin North Am. 2018 Jun;47(2):355-368. doi: 10.1016/j.gtc.2018.01.007. Epub 2018 Apr 4.


Pediatric intestinal transplantation has moved from the theoretic to an actual therapy for children with irreversible intestinal failure who are suffering from complications of total parenteral nutrition. Owing to significant advancement in the management of intestinal failure and prevention of parenteral nutrition-related complications that have led to reduction in incidence of parenteral nutrition-associated liver disease and have improved intestinal adaptation, the indications for intestinal transplantation are evolving. Long-term outcomes have improved, but challenges in long-term graft function owing to chronic rejection and immunosuppressant-related complications remain the major opportunities for improvement.

Keywords: Immunosuppression; Intestinal failure; Pediatric intestinal transplantation; Short gut syndrome.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Composite Tissue Allografts*
  • Graft vs Host Disease / diagnosis
  • Graft vs Host Disease / drug therapy
  • Humans
  • Immunosuppression Therapy
  • Infant
  • Infant, Newborn
  • Infections / drug therapy
  • Infections / etiology
  • Intestinal Diseases / surgery*
  • Intestines / physiopathology
  • Intestines / transplantation*
  • Liver Transplantation
  • Living Donors
  • Organ Transplantation / adverse effects
  • Organ Transplantation / methods*
  • Pancreas Transplantation
  • Patient Selection
  • Postoperative Care*
  • Stomach / transplantation
  • Survival Rate
  • Tissue and Organ Harvesting / methods