Primary cutaneous cribriform apocrine carcinoma: Case report and literature review

Indian J Dermatol Venereol Leprol. 2018 Sep-Oct;84(5):569-572. doi: 10.4103/ijdvl.IJDVL_830_16.


Primary cutaneous cribriform apocrine carcinoma is a rare but distinct variant of primary cutaneous apocrine carcinoma and it is considered a low grade malignancy. We herein present a case of primary cutaneous cribriform apocrine carcinoma at the neck of a 26-year-old female. The tumor features a relatively well-circumscribed border and multiple aggregations of mildly pleomorphic epithelial cells with large ovoid nuclei, small nucleoli and abundant eosinophilic cytoplasms. Cribriform and tubular structures are the major architectural patterns. The primary differential diagnosis is cutaneous metastasis from a cribriform visceral carcinoma; others include primary secretory carcinoma of the skin, adenoid cystic basal cell carcinoma and primary cutaneous adenoid cystic carcinoma.

Keywords: Adenoid cystic carcinoma; apocrine carcinoma; cribriform carcinoma; cutaneous adnexal tumor; secretory carcinoma.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adenocarcinoma / complications
  • Adenocarcinoma / diagnosis*
  • Adult
  • Apocrine Glands / pathology*
  • Diagnosis, Differential
  • Female
  • Humans
  • Sweat Gland Neoplasms / complications
  • Sweat Gland Neoplasms / diagnosis*