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. 2018 Aug;473(2):235-239.
doi: 10.1007/s00428-018-2370-9. Epub 2018 May 7.

β-Catenin (CTNNB1) Mutation and LEF1 Expression in Sinonasal Glomangiopericytoma (Sinonasal-Type Hemangiopericytoma)

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β-Catenin (CTNNB1) Mutation and LEF1 Expression in Sinonasal Glomangiopericytoma (Sinonasal-Type Hemangiopericytoma)

Yuka Suzuki et al. Virchows Arch. .

Abstract

Sinonasal glomangiopericytoma (SN-GPC) is an uncommon mesenchymal tumor with myoid differentiation. Recently, mutations in exon 3 of the gene coding for β-catenin (CTNNB1) and its nuclear expression were discovered in SN-GPC. β-catenin protein is a key regulatory molecule of the canonical Wnt signaling pathway. The expression of β-catenin target proteins is not well characterized in SN-GPC. We examined three SN-GPCs by immunohistochemistry and CTNNB1 mutation analysis. All cases expressed nuclear β-catenin. We identified CTNNB1 exon 3 mutations in two analyzable cases. Lymphoid enhancer-binding factor 1 (LEF1), a protein downstream from β-catenin, was also expressed in all cases. Our results further characterized the activation of the Wnt signaling pathway caused by CTNNB1 exon 3 mutation and suggest the utility of LEF1 immunohistochemistry in the differential diagnosis of SN-GPC.

Keywords: CTNNB1; LEF1; Sinonasal glomangiopericytoma; β-catenin.

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