Excavating Anticonvulsant Compounds from Prescriptions of Traditional Chinese Medicine in the Treatment of Epilepsy

Am J Chin Med. 2018;46(4):707-737. doi: 10.1142/S0192415X18500374. Epub 2018 May 8.


Traditional Chinese medicine (TCM) has a long history and been widely used in prevention and treatment of epilepsy in China. This paper is intended to review the advances in the active anticonvulsant compounds isolated from herbs in the prescription of TCM in the treatment of epilepsy. These compounds were introduced with the details including classification, CAS number specific structure and druggability data. Meanwhile, much of the research in these compounds in the last two decades has shown that they exhibited favorable pharmacological properties in treatment of epilepsy both in in vivo and in vitro models. In addition, in this present review, the evaluation of the effects of the anticonvulsant classical TCM prescriptions is discussed. According to these rewarding pharmacological effects and chemical substances, the prescription of TCM herbs could be an effective therapeutic strategy for epilepsy patients, and also could be a promising source for the development of new drugs.

Keywords: Anticonvulsant Compounds; Epilepsy; Review; Traditional Chinese Medicine.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification
  • Anticonvulsants / chemistry
  • Anticonvulsants / isolation & purification*
  • Anticonvulsants / pharmacology
  • Anticonvulsants / therapeutic use
  • Drug Combinations
  • Drugs, Chinese Herbal / chemistry*
  • Epilepsy / drug therapy*
  • Epilepsy / prevention & control
  • Flavonoids / chemistry
  • Flavonoids / isolation & purification
  • Humans
  • Molecular Conformation
  • Phenols / chemistry
  • Phenols / isolation & purification
  • Phytotherapy*
  • PubMed
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification


  • Alkaloids
  • Anticonvulsants
  • Drug Combinations
  • Drugs, Chinese Herbal
  • Flavonoids
  • Phenols
  • Triterpenes