Sophoflavanones A and B, two novel prenylated flavanones from the roots of Sophora flavescens

Bioorg Chem. 2018 Sep:79:122-125. doi: 10.1016/j.bioorg.2018.04.019. Epub 2018 Apr 26.

Abstract

In our ongoing investigation of the bioactive compounds from the extract of the roots of Sophora flavescens, two novel prenylated flavanones, named sophoflavanones A (1) and B (2), each with an unusual pyran ring were isolated. Their structures, as well as their absolute configurations, were elucidated based on spectroscopic data including a comparison of their experimental and calculated electronic circular dichroism (ECD) spectra. Additionally, compounds 1 and 2 showed moderate antioxidant activities against Fe2+/cysteine-induced toxicity at a concentration of 0.1 µM (inhibition values of 71.65% and 72.49%, respectively, using vitamin C as a positive control (87.83%)).

Keywords: Antioxidant activity; Prenylated flavanone; Sophoflavanone B; Sophoflavanones A; Sophora flavescens.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / chemistry
  • Antioxidants / isolation & purification
  • Antioxidants / pharmacology*
  • Cell Line, Tumor
  • Flavanones / chemistry
  • Flavanones / isolation & purification
  • Flavanones / pharmacology*
  • Humans
  • Microsomes, Liver / metabolism
  • Plant Roots / chemistry*
  • Sophora / chemistry*
  • Stereoisomerism

Substances

  • Antioxidants
  • Flavanones