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Targeting Head and Neck Cancer by Vaccination

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Review

Targeting Head and Neck Cancer by Vaccination

Chuan Wang et al. Front Immunol.

Abstract

Head and neck cancer (HNC) is a heterogeneous group of squamous cell cancers that affect the oral cavity, pharynx, and larynx. Worldwide, it is the sixth most common cancer but in parts of Southern and South-East Asia, HNC is one of the most common cancers. A significant proportion of HNC is driven by human papillomavirus (HPV) infection, whereas HPV-independent HNC is associated with alcohol, smoking, and smokeless tobacco consumption. Here, we review the past and present experience of targeting HNC with vaccination focusing on HPV-derived antigens as well as non-viral antigens for HPV-negative HNC. Novel therapeutic approaches for HNC will focus not only on effective vaccine platforms but will also target the stroma-rich immunosuppressive microenvironment found in those tumours.

Keywords: cancer antigens; cancer vaccines; head and neck cancer; human papillomavirus; human papillomavirus independent.

Figures

Figure 1
Figure 1
Approaches for prophylactic (A) and therapeutic (B) vaccination for head and neck cancer. Abbreviations: VLP, virus-like particle; iTME, immunosuppressive tumour microenvironment; MDSC, myeloid-derived suppressor cell; Treg, regulatory T cell; CAF, cancer-associated fibroblast.

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