Adverse effect of prematurely elevated progesterone in in vitro fertilization cycles: a literature review

Biol Reprod. 2018 Jul 1;99(1):45-51. doi: 10.1093/biolre/ioy082.


Premature progesterone (P) elevation was commonly seen in IVF prior to the utilization of GnRH analogues for suppression of endogenous gonadotropin release. The cause and effect of premature P elevation has finally been better elucidated in the past decade. Although still occurring in 5-38% of all IVF cycles, the adverse effects of premature P elevation on pregnancy outcomes are now well known.

Publication types

  • Review

MeSH terms

  • Embryo Transfer*
  • Female
  • Fertilization in Vitro*
  • Humans
  • Ovulation Induction*
  • Pregnancy
  • Pregnancy Outcome
  • Progesterone / adverse effects*
  • Progesterone / blood*


  • Progesterone