Adverse effect of prematurely elevated progesterone in in vitro fertilization cycles: a literature review

Michael B Evans; Mae W Healy; Alan H DeCherney; Micah J Hill

doi:10.1093/biolre/ioy082

Adverse effect of prematurely elevated progesterone in in vitro fertilization cycles: a literature review

Biol Reprod. 2018 Jul 1;99(1):45-51. doi: 10.1093/biolre/ioy082.

Authors

Michael B Evans¹, Mae W Healy¹, Alan H DeCherney¹, Micah J Hill¹

Affiliation

¹ Program in Reproductive Endocrinology and Gynecology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health. Bethesda, MD, USA.

Abstract

Premature progesterone (P) elevation was commonly seen in IVF prior to the utilization of GnRH analogues for suppression of endogenous gonadotropin release. The cause and effect of premature P elevation has finally been better elucidated in the past decade. Although still occurring in 5-38% of all IVF cycles, the adverse effects of premature P elevation on pregnancy outcomes are now well known.

Publication types

Review

MeSH terms

Embryo Transfer*
Female
Fertilization in Vitro*
Humans
Ovulation Induction*
Pregnancy
Pregnancy Outcome
Progesterone / adverse effects*
Progesterone / blood*

Substances

Progesterone