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Randomized Controlled Trial
. 2018 Jul;66(7):1346-1352.
doi: 10.1111/jgs.15396. Epub 2018 May 9.

Probiotics to Prevent Respiratory Infections in Nursing Homes: A Pilot Randomized Controlled Trial

Biao Wang  1 , Tammy Hylwka  1 , Marek Smieja  1 , Michael Surrette  2 , Dawn M E Bowdish  1 , Mark Loeb  1
Affiliations
Randomized Controlled Trial

Probiotics to Prevent Respiratory Infections in Nursing Homes: A Pilot Randomized Controlled Trial

Biao Wang et al. J Am Geriatr Soc. 2018 Jul.

Abstract

Objectives: To assess the feasibility of conducting a large clinical trial to evaluate the effectiveness of probiotics to reduce influenza and other respiratory virus infections in residents of long-term and chronic care facilities (LTCFs).

Design: Randomized, double-blind, placebo-controlled pilot trial.

Setting: Fourteen nursing homes in Hamilton and surrounding region, Ontario, Canada.

Participants: Nursing home residents aged 65 and older (N=209). Those who were taking immunosuppressives (steroids or other immunosuppressives) or had a hematological malignancy, structural heart disease, or gastroesophageal or intestinal injury and others at high risk of an endovascular infection were excluded.

Intervention: Participants were randomized to receive study probiotics-2 capsules of Lactobacillus rhamnosus GG (estimated 10 billion colony forming units of L. rhamnosus GG per capsule) or placebo (calcium carbonate) daily for 6 months.

Measurements: Laboratory-confirmed respiratory viral infections.

Results: One hundred ninety-six individuals were included in the analysis: 100 in the probiotics group and 96 in the placebo group. Laboratory-confirmed respiratory viral infections were observed in 14 (15.0%) residents in the probiotic group and 21 (22.9%) in the placebo group (hazard ratio=0.65, 95% confidence interval=0.32-1.31).

Conclusion: A larger trial is warranted to determine whether probiotics reduce influenza and other respiratory virus infections in residents of LTCFs.

Trial registration: ClinicalTrials.gov NCT01720329.

Keywords: L. rhamnosus GG; elderly; nursing home; probiotics; respiratory infections.

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