N1-methylnicotinamide (MNAM) as a guardian of cardiovascular system

J Cell Physiol. 2018 Oct;233(10):6386-6394. doi: 10.1002/jcp.26636. Epub 2018 May 9.

Abstract

Atherosclerosis is identified as the formation of atherosclerotic plaques, which could initiate the formation of a blood clot in which its growth to coronary artery can lead to a heart attack. N-methyltransferase (NNMT) is an enzyme that converts the NAM (nicotinamide) to its methylated form, N1-methylnicotinamide (MNAM). Higher levels of MNAM have been reported in cases with coronary artery disease (CAD). Further, MNAM increases endothelial prostacyclin (PGI2) and nitric oxide (NO) and thereby causes vasorelaxation. The vasoprotective, anti-inflammatory and anti-thrombotic roles of MNAM have been well documented; however, the exact underlying mechanisms remain to be clarified. Due to potential role of MNAM in the formation of lipid droplets (LDs), it might exert its function in coordination with lipids, and their targets. In this study, we summarized the roles of MNAM in cardiovascular system and highlighted its possible mode of actions.

Keywords: N-methyltransferase; N1-methylnicotinamide; atherosclerosis; coronary artery disease; lipid droplets.

Publication types

  • Review

MeSH terms

  • Atherosclerosis / genetics*
  • Atherosclerosis / metabolism
  • Cardiovascular System / metabolism*
  • Coronary Artery Disease / genetics*
  • Coronary Artery Disease / metabolism
  • Epoprostenol / genetics
  • Epoprostenol / metabolism
  • Humans
  • Lipid Droplets / metabolism
  • Niacinamide / analogs & derivatives*
  • Niacinamide / genetics
  • Niacinamide / metabolism
  • Nitric Oxide / metabolism

Substances

  • Niacinamide
  • Nitric Oxide
  • Epoprostenol
  • N(1)-methylnicotinamide