In view of the excellent biocompatibility as well as the low cost, nanoscale ZnO shows great potential for drug delivery application. Moreover, The charming character enable nanoscale ZnO some excellent features (e.g. dissolution in acid, ultrasonic permeability, microwave absorbing, hydrophobic/hydrophilic transition). All of that make nanoscale ZnO reasonable choices for smart drug delivery. In the recent decade, more and more studies have focused on controlling the drug release behavior via smart drug delivery systems based on nanoscale ZnO responsive to some certain stimuli. Herein, we review the recent exciting progress on the pH-responsive, ultrasound-responsive, microwave-responsive and UV-responsive nanoscale ZnO-based drug delivery systems. A brief introduction of the drug controlled release behavior and its effect of the drug delivery systems is presented. The biocompatibility of nanoscale ZnO is also discussed. Moreover, its development prospect is looked forward.
氧化锌（ZnO）价格低廉，来源广泛，具有良好的生物相容性。更为重要的是，特殊的光电性能赋予纳米 ZnO 许多优良的特性（如：溶解于酸、超声波易渗透、吸收微波、亲/疏水态转变等）。这些优良的特性使得纳米 ZnO 成为制备智能药物载体材料的理想选择。近些年来，基于纳米 ZnO 的智能药物载体的研究也备受关注。因此，本文主要介绍 pH 响应、超声波响应、微波响应以及紫外光响应的基于纳米 ZnO 的智能药物载体药物控制行为及其在体内外实验中的应用效果，同时讨论了纳米 ZnO 的生物相容性，并展望了基于纳米 ZnO 的智能药物载体的发展前景。.
Keywords: biocompatibility; controlled-release; drug delivery systems; smart response; zinc oxide.