Laryngeal diseases are closely related to the swallowing and speech function of the patients.Protecting and restoring laryngeal function, while curing lesions, is vital to patients' quality of life.Photodynamic therapy (PDT) is a minimally invasive method which is widely used in the treatment of tumor, precancerous lesions, and inflammatory diseases.In recent years, it has been shown to have a protective effect on normal structures. This article reviews the clinical outcomes of laryngeal diseases treated with PDT since 1990 in order to evaluate its efficacy and significance. The complete remission rate of early-stage laryngeal tumors and precancerous lesions after PDT is 77.6%(249/321), and a promising effect on recurrent laryngeal papillomatosis has been observed thus far. The prolonged adverse effects of the first-generation photosensitizers have limited the application of PDT. With the improvement of photosensitizers and treatment strategies, PDT promises to be a safe, effective, and minimally invasive treatment method for laryngeal diseases.
咽喉疾病与患者的吞咽和言语功能密切相关，在治疗疾病的同时保护和恢复咽喉功能对于患者的生活质量十分重要。光动力治疗(photodynamic therapy，PDT)是一种微创治疗手段，近年来广泛应用于肿瘤、癌前病变和炎性反应等疾病的治疗，对正常结构具有较好的保护作用。本文综述了自1990年以来国内外文献中有关PDT对咽喉疾病治疗的临床数据，评估其应用价值。PDT治疗早期咽喉恶性肿瘤和癌前病变的完全缓解率达77.6%(249/321)，对复发性喉乳头状瘤也有一定疗效，但第一代光敏剂的不良反应较重，限制了其在咽喉疾病中的应用。随着光敏剂特性和治疗技术的改进，PDT有希望成为咽喉疾病的一种安全、有效、微创的常规治疗手段。.
Keywords: Laryngeal neoplasms; Papilloma; Photochemotherapy; Precancerous conditions; Surgical procedures, minimally invasive therapy.