Thromboprophylaxis in Pregnancy

Diana Kolettis; Sabrina Craigo

doi:10.1016/j.ogc.2018.01.007

Thromboprophylaxis in Pregnancy

Obstet Gynecol Clin North Am. 2018 Jun;45(2):389-402. doi: 10.1016/j.ogc.2018.01.007.

Authors

Diana Kolettis¹, Sabrina Craigo²

Affiliations

¹ Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Tufts Medical Center, 800 Washington Street, Box 360, Boston, MA 02111, USA.
² Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Tufts Medical Center, 800 Washington Street, Box 360, Boston, MA 02111, USA. Electronic address: scraigo@tuftsmedicalcenter.org.

PMID: 29747737
DOI: 10.1016/j.ogc.2018.01.007

Abstract

Venous thromboembolism is a leading cause of maternal morbidity and mortality worldwide. Identifying women who are at greatest risk for venous thromboembolism, and managing their pregnancies with appropriate thromboprophylaxis is essential to decreasing this life-threatening condition. Those at greatest risk are patients with thrombophilias, a personal or family history of venous thromboembolism, and those undergoing cesarean delivery. Current international guidelines on thromboprophylaxis vary in details, but all strategies rely on risk factor identification and thromboprophylaxis for the highest risk patients. All guidelines require clinicians to think critically about individual patient's risk factors throughout pregnancy and the postpartum period.

Keywords: Pregnancy; Prophylaxis; Thromboembolism; Thromboprophylaxis.

Publication types

Review

MeSH terms

Cesarean Section / adverse effects
Chemoprevention
Female
Humans
Pregnancy
Pregnancy Complications, Hematologic / etiology
Pregnancy Complications, Hematologic / prevention & control*
Pulmonary Embolism / etiology
Pulmonary Embolism / prevention & control
Risk Assessment
Risk Factors
Venous Thromboembolism / etiology
Venous Thromboembolism / prevention & control*
Venous Thrombosis / etiology
Venous Thrombosis / prevention & control