KRAS Activating Signaling Triggers Arteriovenous Malformations

Trends Biochem Sci. 2018 Jul;43(7):481-483. doi: 10.1016/j.tibs.2018.04.007. Epub 2018 May 7.

Abstract

The underlying genetic causes and altered signaling pathways of brain arteriovenous malformations remain unknown. A study published in The New England Journal of Medicine reported that KRAS somatic mutations (p.Gly12Val/Asp) were identified in brain arteriovenous malformations of human subjects and endothelial cell-enriched cultures, which might specifically activate the MAPK (mitogen-activated protein kinase)-ERK (extracellular signal-regulated kinase) signaling pathway in brain endothelial cells.

Keywords: KRAS; KRAS4A; brain arteriovenous malformations; endothelial cells; somatic mutation.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Arteriovenous Malformations
  • Extracellular Signal-Regulated MAP Kinases
  • Humans
  • MAP Kinase Signaling System
  • Mutation*
  • Proto-Oncogene Proteins p21(ras) / genetics
  • Signal Transduction*

Substances

  • KRAS protein, human
  • Extracellular Signal-Regulated MAP Kinases
  • Proto-Oncogene Proteins p21(ras)