Self-Reported Non-adherence to Medication in Japanese Patients with Cardiovascular Diseases

Am J Cardiovasc Drugs. 2018 Aug;18(4):311-316. doi: 10.1007/s40256-018-0278-z.


Objective: Non-adherence to medication is an important problem in cardiovascular treatment. The aim of this study was to assess self-reported non-adherence in Japanese patients with cardiovascular disease.

Methods: A total of 1372 outpatients at three university hospitals who completed self-reported questionnaires were analyzed in this prospective study (mean age 67 ± 12 years; 31% female). Self-reported adherence to cardiovascular drugs was measured with a modified Siegal scale. Depressive symptoms were defined as a Patient Health Questionnaire-9 score of ≥ 10.

Results: A total of 227 patients (17%) were defined as non-adherent. Multiple logistic regression analysis showed that ≥ 2 times daily dosing frequency, age < 65 years and active employment were significantly associated with non-adherence, with odds ratios of 4.42 [95% confidence interval (CI) 3.02-6.48], 1.70 (95% CI 1.23-2.35) and 1.43 (95% CI 1.03-1.99), respectively. However, depression was not a significant factor in non-adherence.

Conclusions: Our study showed that self-reported non-adherence to medications was 17% in Japanese patients with cardiovascular disease in the university hospital setting. Daily dosing frequency, younger age and employment were significantly associated with non-adherence.

Trial registration: University hospital Medical Information Network Clinical Trials Registry (UMIN-CTR) no. UMIN 000023514.

Publication types

  • Observational Study

MeSH terms

  • Aged
  • Asians
  • Cardiovascular Agents / therapeutic use*
  • Cardiovascular Diseases / drug therapy*
  • Female
  • Humans
  • Male
  • Medication Adherence / statistics & numerical data*
  • Middle Aged
  • Prospective Studies
  • Registries
  • Self Report
  • Surveys and Questionnaires


  • Cardiovascular Agents