miRNA-489 as a biomarker in diagnosis and treatment of cervical cancer

Bratisl Lek Listy. 2018;119(5):278-283. doi: 10.4149/BLL_2018_052.

Abstract

miRNA-489 was shown to be a suppressor factor in many cancers, however, evidence on the effects and mechanism of miRNA-489 in progression of cervical cancer is limited. So we aimed to determine the function of miRNA-489 in cervical cancer proliferation and apoptosis in our present study. Interestingly, we found that miRNA-489 was significantly down-regulated in cervical cancer tissues. miRNA-489 overexpression inhibited the cell proliferation and improved the cell apoptosis of cervical cancer cells. Further, miRNA-489 over-expression suppressed the activation of PI3K and AKT, and stimulated P53 proteins expression. In conclusion, our results suggested that miRNA-489 may be considered as a biomarker in cervical cancer and had suppressed the cell proliferation and stimulated cell apoptosis via PI3K/AKT/P53 signaling pathway (Fig. 5, Ref. 26). Text in PDF www.elis.sk.

Keywords: AKT; P53 biomarker.; PI3K; miRNA-489.

MeSH terms

  • Apoptosis
  • Biomarkers
  • Cell Line, Tumor
  • Cell Proliferation
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • MicroRNAs* / analysis
  • Phosphatidylinositol 3-Kinases
  • Proto-Oncogene Proteins c-akt
  • Uterine Cervical Neoplasms* / diagnosis
  • Uterine Cervical Neoplasms* / genetics
  • Uterine Cervical Neoplasms* / therapy

Substances

  • Biomarkers
  • MIRN489 microRNA, human
  • MicroRNAs
  • Phosphatidylinositol 3-Kinases
  • Proto-Oncogene Proteins c-akt