Cell of origin dictates aggression and stem cell number in acute lymphoblastic leukemia

Elaine G Garcia; Sowmya Iyer; Sara P Garcia; Siebe Loontiens; Ruslan I Sadreyev; Frank Speleman; David M Langenau

doi:10.1038/s41375-018-0130-0

Cell of origin dictates aggression and stem cell number in acute lymphoblastic leukemia

Leukemia. 2018 Aug;32(8):1860-1865. doi: 10.1038/s41375-018-0130-0. Epub 2018 Apr 18.

Authors

Elaine G Garcia^{1

2

3

4}, Sowmya Iyer^{1

2

3

4}, Sara P Garcia^{1

2

3

4}, Siebe Loontiens⁵, Ruslan I Sadreyev^{1

4}, Frank Speleman⁵, David M Langenau^{6

7

8

9}

Affiliations

¹ Department of Pathology, Massachusetts General Hospital Research Institute, Boston, MA, 02114, USA.
² Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, 02129, USA.
³ Harvard Stem Cell Institute, Boston, MA, 02114, USA.
⁴ Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
⁵ Cancer Research Institute Ghent (CRIG) and Center for Medical Genetics, Ghent University, Ghent, Belgium.
⁶ Department of Pathology, Massachusetts General Hospital Research Institute, Boston, MA, 02114, USA. dlangenau@mgh.harvard.edu.
⁷ Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, 02129, USA. dlangenau@mgh.harvard.edu.
⁸ Harvard Stem Cell Institute, Boston, MA, 02114, USA. dlangenau@mgh.harvard.edu.
⁹ Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA. dlangenau@mgh.harvard.edu.

No abstract available

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Animals, Genetically Modified
B-Lymphocytes / pathology*
Cell Lineage*
Clone Cells / pathology*
Humans
Neoplastic Stem Cells / pathology*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology*
T-Lymphocytes / pathology*
Tumor Cells, Cultured
Zebrafish

Publication types

MeSH terms

Grants and funding