Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Filters applied. Clear all
Meta-Analysis
. 2019 Feb;13(1):3-17.
doi: 10.1111/eip.12677. Epub 2018 May 11.

Attenuated Psychotic Symptom Interventions in Youth at Risk of Psychosis: A Systematic Review and Meta-Analysis

Affiliations
Free PMC article
Meta-Analysis

Attenuated Psychotic Symptom Interventions in Youth at Risk of Psychosis: A Systematic Review and Meta-Analysis

Daniel J Devoe et al. Early Interv Psychiatry. .
Free PMC article

Abstract

Aim: Attenuated psychotic symptoms (APSs) have been the primary emphasis in youth at clinical high risk (CHR) for psychosis for assessing symptomology and determining subsequent transition to a psychotic disorder. Previous reviews primarily focused on the efficacy of cognitive behavioural therapy (CBT) on APS; however, a comprehensive assessment of other interventions to date is lacking. Therefore, we conducted a systematic review and meta-analysis of all intervention studies examining APS in CHR youth.

Method: The authors searched Embase, CINAHL, PsycINFO, Medline and EBM from inception to May 2017. Studies were selected if they included any intervention that reported follow-up APS in youth at CHR. Interventions were evaluated and stratified by time using both pairwise and network meta-analyses (NMAs). Due to the differences in APS scales, effect sizes were calculated as Hedges g and reported as the standardized mean difference (SMD).

Results: Forty-one studies met our inclusion criteria. In pairwise meta-analyses, CBT was associated with a trend towards reduction in APS compared to controls at 12-months. In the NMA, integrated psychological therapy, CBT, supportive therapy, family therapy, needs-based interventions, omega-3, risperidone plus CBT and olanzapine were not significantly more effective at reducing APS at 6 and 12 months relative to any other intervention.

Conclusions: CBT demonstrated a slight trend at reducing APS at long-term follow-up compared to controls. No interventions were significantly more effective at reducing APS compared to all other interventions in the NMA. [Correction added on 4 June 2018, after first online publication: Some parts of the Abstract section particularly 'Results' and 'Conclusions' have been corrected.].

Keywords: clinical high risk; meta-analysis; schizophrenia; systematic review.

Figures

Figure 1
Figure 1
PRISMA flow diagram of systematic search and included studies.
Figure 2
Figure 2
Figure 2
Figure 2
Figure 3
Figure 3
Figure 3
Figure 3
Figure 4
Figure 4
Figure 4
Figure 4

Similar articles

See all similar articles

Cited by 15 articles

See all "Cited by" articles

Publication types

MeSH terms

Feedback