Candidate gene analysis of asthma in a population of Arab descent: a case-control study in Jordan

Per Med. 2017 Jan;14(1):51-61. doi: 10.2217/pme-2016-0059. Epub 2016 Nov 30.

Abstract

Aim: To evaluate whether SNPs (n = 15) in ten candidate genes (ADRB2, ADH5, ARGI, CRHR1, STIP1, LTA4H, LTC4S, ALOX5, ABCC1 and OATP2B1) are associated with asthma in Jordanian population of Arab descent.

Methods: A case-control study included 245 adult asthmatics and 249 controls.

Results: Significant genetic association was identified at the rs2236647 (T/C) SNP in STIP1 and risk of asthma (p < 0.001). The C allele and CC genotype of this SNP were significantly higher in asthmatics compared with controls. The rs1141370 SNP (Val34Met) in ADRB2 is not polymorphic in our cohort.

Conclusion: The rs2236647 SNP could act as a reliable tool to identify individuals at risk of developing asthma and provision of early intervention in population of Arab descent.

Keywords: Arab; Jordan; SNP; STIP1; asthma; genetic association.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Arabs / genetics
  • Asthma / genetics*
  • Case-Control Studies
  • Cohort Studies
  • Female
  • Gene Frequency / genetics
  • Genetic Association Studies / methods
  • Genetic Predisposition to Disease / genetics
  • Genetic Testing / methods
  • Genotype
  • Haplotypes
  • Heat-Shock Proteins / genetics*
  • Heat-Shock Proteins / metabolism
  • Humans
  • Jordan
  • Male
  • Polymorphism, Single Nucleotide / genetics
  • Precision Medicine / methods
  • Young Adult

Substances

  • Heat-Shock Proteins
  • STIP1 protein, human