LEPR gene polymorphism and plasma soluble leptin receptor levels are associated with polycystic ovary syndrome in Han Chinese women

Per Med. 2017 Jul;14(4):299-307. doi: 10.2217/pme-2017-0016. Epub 2017 Jun 15.


Aim: To investigate the association of LEPR polymorphisms and plasma leptin and soluble leptin receptor (sOB-R) levels with polycystic ovary syndrome (PCOS) in Chinese women.

Patients & methods: LEPR Lys109Arg (rs1137100) and Gln223Arg (rs1137101) polymorphisms of PCOS patients and the controls were genotyped. Plasma leptin and sOB-R levels of two groups were measured.

Results: The genotypic distributions of Lys109Arg (rs1137100) differed between the PCOS and control groups. Plasma sOB-R levels increased significantly in PCOS patients and were associated with PCOS independent of BMI. Furthermore, luteinizing hormone, triglyceride and fasting blood glucose correlated significantly to PCOS patients' sOB-R levels.

Conclusion: LEPR Lys109Arg (rs1137100) was associated with PCOS susceptibility and genotype AA was deduced to be a protective factor for PCOS; sOB-R levels might be recognized as a new indicator for the severity of PCOS.

Keywords: association; indicator; leptin; leptin receptor; polycystic ovary syndrome; single nucleotide polymorphisms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Asian People / genetics
  • Case-Control Studies
  • China
  • Ethnicity / genetics
  • Female
  • Gene Expression
  • Gene Frequency / genetics
  • Genotype
  • Humans
  • Leptin / blood
  • Polycystic Ovary Syndrome / genetics*
  • Polycystic Ovary Syndrome / metabolism
  • Polymorphism, Single Nucleotide / genetics
  • Receptors, Leptin / analysis
  • Receptors, Leptin / genetics*
  • Receptors, Leptin / metabolism


  • LEPR protein, human
  • Leptin
  • Receptors, Leptin