First Metal-Free Synthesis of Tetracyclic Pyrido and Pyrazino Thienopyrimidinone Molecules

Molecules. 2018 May 11;23(5):1159. doi: 10.3390/molecules23051159.

Abstract

We report herein a new metal free synthetic pathway to generate tetracyclic compounds from 3-aminothieno[3,2-b]pyridine-2-carboxylate. To enlarge the molecular diversity, we studied the Suzuki coupling of 9-chloro-6H-pyrido[1,2-a]pyrido[2',3':4,5]thieno[3,2-d]pyrimidin-6-one and several boronic acids were easily introduced.

Keywords: metal-free; tetracyclic compounds; thienopyrimidinone.

MeSH terms

  • Chemistry Techniques, Synthetic
  • Cyclization
  • Molecular Structure
  • Pyridines / chemistry
  • Pyrimidines / chemical synthesis*
  • Pyrimidines / chemistry

Substances

  • Pyridines
  • Pyrimidines
  • thienopyrimidine