QuantiFERON-TB Gold In-tube test for the diagnosis of active and latent tuberculosis in selected health facilities of Addis Ababa, Ethiopia

BMC Res Notes. 2018 May 11;11(1):293. doi: 10.1186/s13104-018-3410-x.

Abstract

Objective: To determine the performance of QuantiFERON-TB IN-Gold for the diagnosis active tuberculosis and latent tuberculosis.

Results: A total of 213 participants (136 tuberculosis suspects, 66 latently infected) were enrolled. Of 213, 21 (15.4%) of the tuberculosis suspects and 3 (4.5%) of the latent tuberculosis groups were human immunodeficiency virus infected. The sensitivity, specificity, positive and negative predictive value of QuantiFERON-TB IN-Gold for the diagnosis of active tuberculosis was 70.3% (26/37), 49.5% (49/99), 34.7% (26/75) and 83.1% (49/59) respectively. A kappa value of 0.316 (p = 0.001, 95% CI 1.605-1.609) between QuantiFERON-TB IN-Gold and tuberculin skin test were found.

Keywords: Active tuberculosis; Addis Ababa; Human immunodeficiency virus; Latent tuberculosis; QuantiFERON-TB IN-Gold; Tuberculin skin test.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Cross-Sectional Studies
  • Ethiopia / epidemiology
  • Female
  • HIV Infections / epidemiology
  • Humans
  • Interferon-gamma Release Tests / standards*
  • Latent Tuberculosis / blood
  • Latent Tuberculosis / diagnosis
  • Latent Tuberculosis / epidemiology
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Sensitivity and Specificity
  • Tuberculin Test / standards*
  • Tuberculosis / blood
  • Tuberculosis / diagnosis*
  • Tuberculosis / epidemiology
  • Young Adult