Chronic Hepatitis C and Direct Acting Antivirals

Surg Pathol Clin. 2018 Jun;11(2):287-296. doi: 10.1016/j.path.2018.02.002. Epub 2018 Mar 26.


The hepatitis C virus (HCV) is the most common blood-borne infection in the United States and is the most common cause of end-stage liver disease requiring liver transplant. Over the last 10 years, direct acting antiviral therapies have revolutionized HCV treatment, increasing the cure rates from less than 50% to more than 90% in those who reach access to care. This article is an overview for pathologists and clinicians covering the histologic findings of HCV as well as direct acting antiviral therapy.

Keywords: Diagnostic criteria; Directly acting antivirals; Hepatitis C; Histology; Liver biopsy; Transient elastography.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Antiviral Agents / therapeutic use*
  • Biopsy
  • Hepatitis C / pathology
  • Hepatitis C, Chronic / diagnosis
  • Hepatitis C, Chronic / drug therapy*
  • Hepatitis C, Chronic / pathology
  • Humans
  • Liver / pathology


  • Antiviral Agents