Hepatic Lymphoma Diagnosis

Surg Pathol Clin. 2018 Jun;11(2):389-402. doi: 10.1016/j.path.2018.02.003. Epub 2018 Mar 21.


Systemic hematopoietic disorders may present on liver biopsy, and rare cases of primary hepatic lymphoma (PHL) may be encountered. Hepatopathologists must be familiar with the full spectrum of hematopoietic disorders involving the liver and be prepared to exclude benign mimics. PHL, which is confined to the liver without extrahepatic involvement, can present as solitary or multiple nodules, raising consideration for carcinoma on imaging, or may mimic benign inflammatory conditions, posing a diagnostic challenge. This article describes clinical, morphologic, and immunophenotypic features of some of the most common hematopoietic neoplasms involving the liver, along with differential diagnosis and recommended ancillary testing.

Keywords: Aggressive NK-cell leukemia; B-lymphoblastic leukemia/lymphoma; Burkitt lymphoma; Chronic lymphocytic leukemia/small lymphocytic lymphoma; Classic Hodgkin lymphoma; Diffuse large B-cell lymphoma; Follicular lymphoma; Hairy cell leukemia.

Publication types

  • Review

MeSH terms

  • Diagnosis, Differential
  • Hodgkin Disease / diagnosis*
  • Hodgkin Disease / pathology
  • Humans
  • Liver Neoplasms / diagnosis*
  • Liver Neoplasms / pathology
  • Lymphoma, B-Cell / diagnosis
  • Lymphoma, B-Cell / pathology
  • Lymphoma, Non-Hodgkin / diagnosis*
  • Lymphoma, Non-Hodgkin / pathology
  • Lymphoma, T-Cell / diagnosis
  • Lymphoma, T-Cell / pathology