Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jul;25(21):20670-20679.
doi: 10.1007/s11356-018-2206-9. Epub 2018 May 12.

Lead Exposure Is Associated With Risk of Impaired Coagulation in Preschool Children From an E-Waste Recycling Area

Affiliations

Lead Exposure Is Associated With Risk of Impaired Coagulation in Preschool Children From an E-Waste Recycling Area

Zhijun Zeng et al. Environ Sci Pollut Res Int. .

Abstract

Environmental lead exposure leads to various deleterious effects on multiple organs and systems, including the hematopoietic system. To explore the effects of lead exposure on platelet indices in preschool children from an informal, lead-contaminated electronic waste (e-waste) recycling area, we collected venous blood samples from 466 preschool children (331 from an e-waste area (Guiyu) and 135 from a non-e-waste area (Haojiang)). Child blood lead levels (BLLs) were determined by graphite furnace atomic absorption spectrophotometry, while platelet indices were quantified using a Sysmex XT-1800i hematology analyzer. Higher blood lead levels are observed in e-waste lead-exposed preschool children. Significant relationships between high blood lead levels (exceeding current health limits) and elevated platelet count (PLT), plateletcrit (PCT), mean platelet volume (MPV), and platelet large cell ratio (P-LCR) were also uncovered. Furthermore, the median PLT and PCT levels of children from the exposed group both exceeded the respective recommended maximum reference range value, whereas the reference group did not. Location of child residence in Guiyu and BLLs were both risk factors related to platelet indices. These results suggest that high blood lead exposure from e-waste recycling may increase the risk of an amplified coagulation process through the activation of platelets in preschool children.

Keywords: Blood coagulation; Blood lead; Electronic waste (e-waste); Platelet indices; Preschool children.

Similar articles

See all similar articles

Cited by 1 article

References

    1. Platelets. 2002 Aug-Sep;13(5-6):301-6 - PubMed
    1. Front Med. 2015 Jun;9(2):220-8 - PubMed
    1. Environ Sci Pollut Res Int. 2017 Oct;24(28):22613-22621 - PubMed
    1. Environ Health Perspect. 2007 Jul;115(7):1113-7 - PubMed
    1. Thromb Haemost. 2003 Jul;90(1):116-23 - PubMed

MeSH terms

LinkOut - more resources

Feedback